Proviten N IV Injection/Infusion 1 Vial

✔️ Proviten N IV for Injection/Infusion:

Each vial contains:

• Vitamin A: 3500 IU
• Vitamin D3: 220 IU
• Vitamin E: 11.20 mg
• Vitamin C: 125 mg
• Vitamin B1 (Thiamine): 3.51 mg
• Vitamin B2 (Riboflavin): 4.14 mg
• Vitamin B6 (Pyridoxine): 4.53 mg
• Vitamin B12 (Cyanocobalamin): 0.006 mg
• Folic Acid: 0.414 mg
• Pantothenic Acid: 17.25 mg
• Biotin: 0.069 mg
• Nicotinamide: 46 mg

✔️ Commercial Pack

Each box contains:

• One vial of multivitamin
• One 5 ml sterile disposable syringe
• One 100 ml normal saline bottle
• One infusion set
• A hanger, a first aid band, and an alcohol pad.

✔️ Side Effects

• Anaphylactic reactions (rare) may occur, especially from thiamine.
• Urticaria and rash have been associated with this preparation.
• Very rare reports of anaphylactic reactions after fast IV injection/infusion over 1–4 minutes.

✔️ Proviten IV is indicated for:

• Daily multivitamin maintenance for adults and children (aged 11 and above) receiving parenteral nutrition.
• Situations requiring IV administration such as surgery, burns, fractures, severe infections, and comatose states.

✔️ Dosage & Administration

Dosage:

• Adults and children (11 years and older): 1 vial/day.

Administration:

• Reconstitute the single-dose vial with 5 ml of sterile water, 0.9% sodium chloride, or 5% glucose.
• Administer by slow IV injection (over at least 10 minutes) or dilute further for IV infusion.
• To minimize vitamin losses, mix the vitamins immediately before administration and use within 24 hours.

✔️ Overdose of Proviten N

• Prolonged administration of high doses can lead to the accumulation of Vitamins A and D.

✔️ Use in Pregnancy & Lactation

• Not extensively studied in humans during pregnancy. Use only if needed.
• Not recommended for lactating women.

✔️ Drug Interactions

• a1-acid glycoprotein-binding drugs (e.g., propranolol, prazosin, quinidine): Close monitoring is required.
• Folic acid: May increase the metabolism of antiepileptics like phenobarbital, phenytoin, and primidone.
• Pyridoxine: This may reduce the effectiveness of levodopa.
• Bleomycin: Can be inactivated by ascorbic acid and riboflavin.

✔️ Precautions

• Anaphylactic reactions: Particularly in patients allergic to thiamine (Vitamin B1) and nicotinamide. Mild reactions such as sneezing or asthma may be warning signs.
• Liver function: Patients with jaundice or cholestasis should be closely monitored due to glycolic acid content.
• Kidney function: Fat-soluble vitamin levels should be monitored in cases of renal impairment.

✔️ Storage

• Store below 30°C before reconstitution, protect from light and do not freeze.
• After reconstitution, store at 2°C to 8°C and use within 24 hours. Discard any unused portion.